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Multi-drug CRIs Advanced

Controlled-drug waste from a partially used MLK bag

You built the MLK bag from problem 4 (50 mg morphine, 400 mg lidocaine, 100 mg ketamine in 250 mL). The patient was extubated and recovered well after ~15 hours and the CRI was discontinued with 100 mL remaining in the bag. How much of each controlled drug needs to be logged as waste?

mg
mg
DEA schedule of morphine
Hint

The bag is a uniform mixture. If you know the fraction of the bag that wasn't given, that same fraction of every drug in the bag was wasted.

Another hint

Wasted fraction = volume remaining ÷ bag volume. Then for each drug: mg wasted = total mg in bag × wasted fraction. Lidocaine isn't federally controlled, but the math is the same.

Show worked answer
  1. First, identify the wasted-volume fraction. 100 mL of a 250 mL bag = 100 / 250 = 0.4, or 40 % of the bag was wasted.

  2. Each drug in the bag is wasted proportionally. Morphine wasted = total mg × wasted fraction. mg stays, the dimensionless fraction multiplies through.

    $$50 \,mg \times 0.4 = 20 \,mg \text{ morphine (C-II)}$$
  3. Same approach for ketamine.

    $$100 \,mg \times 0.4 = 40 \,mg \text{ ketamine (C-III)}$$
  4. Lidocaine is not federally controlled, but you can compute it the same way for completeness.

    $$400 \,mg \times 0.4 = 160 \,mg \text{ lidocaine}$$
  5. Optional: stock-equivalent volumes for logs that record mL. Divide each wasted mg by its stock concentration.

    $$\tfrac{20\,\cancel{mg}}{5\,\cancel{mg}/mL} = 4\,mL \text{ morphine stock-equivalent}$$
  6. The physical waste is 100 mL of diluted bag mixture, not undiluted stock. Most controlled-drug logs want the mg figure since that's what reconciles against your inventory.

  7. On the schedules: morphine is DEA Schedule II (C-II), a full µ-agonist opioid with high abuse potential and accepted medical use. Ketamine is Schedule III (C-III). Both require controlled-drug logging; lidocaine is not federally scheduled. State scheduling can differ, and individual practices may have stricter internal policies.

Answer

Log 20 mg morphine (C-II) and 40 mg ketamine (C-III) as waste. Lidocaine is not federally controlled but 160 mg was discarded with the bag.